作者：訾捷，郭兰敏，范全心，邹承伟

【摘要】  目的观察体外循环（extracorporeal circulation，ECC）手术后S100β 蛋白血浆浓度的变化，比较离心泵和滚压泵对S100β 释放的影响。方法选取20例行双瓣膜置换手术的患者随机分为两组，ECC使用离心泵组（CP组，n=9）和使用滚压泵组（RP组,n=11），分别在ECC开始前、ECC结束时和ECC结束后4 h、12 h抽血检测S100β 蛋白血浆浓度。结果ECC开始前两组血浆中均未检测到S100β ，两组均是在ECC结束时S100β 血浆浓度最高，此后逐渐下降。两组相比较，ECC结束时无显著差异，而在ECC结束后4 h和12 h两组有显著性差别，滚压泵组比离心泵组释放S100β 多。结论ECC使应用离心泵时术后早期释放的S100β比滚压泵的少，提示在时间较长的ECC中应用离心泵可能有利于减轻ECC对脑组织的损伤。

【关键词】  离心泵；滚压泵；S100β 蛋白；体外循环；脑损伤

　　The Influence of Roller and Centrifugal Pump on Plasma S100β Protein Release after Extracorporeal Circulation

　　Abstract: OBJECTIVE To investigated the change of S100β  plasma concentrations during and after extracorporeal circulation（ECC）, compared the influence of roller pump and centrifugal pump on S100β  releasel .METHODS20 patients underwent double valves replacement were randomly divided into two groups: centrifugal (CP, n=9) versus roller (RP, n=11) pump. The CP group used a Jostra centrifugal pump and the RP group a Stochert roller pump for ECC. Before the start of ECC, at the end of ECC and 4 hours, 12 hours after ECC termination, whole blood was taken from radial artery indwelling tube. The plasma levels of S100β were assayed by radioimmuno-assay(RIA) method.RESULTSBoth groups were matched for age, body weight and cardiopulmonary bypass and cross-clamp time. S100β was not found inboth group  before the start of ECC. At the end of ECC, the plasma concentrations of S100β got to peak values, but there was no significant difference between two groups. 4  hours and 12 hours after ECC termination, S100β levels in CP group were significanly lower than RP group.CONCLUSIONS100β  plasma levels increase after ECC，and centrifugal pumps  can significantly decrease it, which  indicate that using centrifugal pumps in ECC  maybe have a more neuroprotective effect than roller pumps.

　　Key words：Roller pump； Centrifugal pump；S100β；Extracorporeal circulation；Cerebral injury

　　体外循环（extracorporeal circulation，ECC）手术可以引起脑功能和结构损害。 S100β 是一种存在于星形胶质细胞和雪旺氏细胞的酸性钙结合蛋白，当神经组织损伤时脑脊液和血液内的浓度均增高。本研究用S100β 作为脑损伤的标志，观察ECC手术前后S100β 变化，比较应用离心盚TTP/1.1 200 OK Server: Huadun-Server/3.0 Content-Length: 336 Content-type: text/html /> -->