作者:赵慈宝，沈金贵，夏泽兵

［摘要］  目的  观察125I 放射微粒植入对直肠癌术后盆腔局部复发的治疗效果。方法  对12例临床确诊直肠癌术后盆腔局部复发，在癌组织间植入125I放射微粒，每例平均36粒，术后复查B超、观察对照。结果  采用经尾骶部或经腹进入，部分切除盆腔复发肿块+125I粒子植入治疗方法，手术过程顺利，3个月后经B超及CT示肿块，会阴部、骶尾部胀痛以及阴茎龟头疼痛明显缓解，双侧输尿管扩张、肾盂积水消失及肾功能亦得到不同程度恢复。结论  125I 放射微粒植入方法，对直肠癌根治手术后盆腔局部复发无法再手术的患者，治疗安全性好、效果可靠。
   
    ［关键词］  直肠癌；术后；局部复发；放射性碘
   
    125I in treatment of local recurrence of colorectal carcinoma in pelvic cavity post-operatively
    
    ［Abstract］  Objective  To observe effects of 125I particle on local recurrence of colorectal carcinoma post-operatively.Methods  Twelve cases of recurrent colorectal carcinoma in pelvic cavity were under one 125I particle implanting，36 particles per case.B ultrasound was used to observe the curative efficacy.Transabdominal or transcaudal entry，partially resecting tumor+125I particle implanting were performed.Results  Three months later，B ultrasound and CT were used to detect the tumor，swollen pain in perineum，glans and caudal were relieved，bilateral ureter were expanded and hydronephrosis was disappear，renal function restored partially.Conclusion  125I particle implanting plays a role in treatment of local recurrence of colorectal carcinoma post-operatively，especially for those intolerance of operation.
   
    ［Key words］  colorectal carcinoma;postoperatiue period;local recurrence;125I
   
    在我国直肠癌约占大肠癌的2/3左右，手术切除是直肠癌首选的治疗方法。直肠癌根治手术后盆腔、吻合口、会阴部等局部复发相当常见［1］，局部复发率受诸多因素影响，一般在4%～51%，近来报道复发率多下降到10%以下［2］。局部复发的治疗非常困难，扩大再切除只适用于少数病人，手术风险大，疗效差。
   
    我院自2003年5月～2005年6月收治直肠癌根治手术后盆腔、会阴部等局部复发患者27例，采用外照射加化疗15例HTTP/1.1 200 OK Server: Huadun-Server/3.0 Content-Length: 334 Content-type: text/html /> -->